Unique Endotoxin-Neutralizing Proteins
نویسندگان
چکیده
منابع مشابه
Endotoxin-neutralizing antimicrobial proteins of the human placenta.
Microbial colonization and infection of placental tissues often lead to adverse pregnancy outcomes such as preterm birth, a leading cause of neonatal morbidity and mortality. The fetal membranes of the placenta, a physical and active barrier to microbial invasion, encapsulate the fetus and secure its intrauterine environment. To examine the innate defense system of the human placenta, antimicro...
متن کاملEndotoxin-neutralizing protein protects against endotoxin-induced endothelial barrier dysfunction.
Bacterial lipopolysaccharide induces tyrosine phosphorylation of paxillin, actin reorganization, and opening of the transendothelial paracellular pathway through which macromoles flux. In this study, lipid A was shown to be the bioactive portion of the lipopolysaccharide molecule responsible for changes in endothelial barrier function. We then studied whether endotoxin-neutralizing protein, a r...
متن کاملLipopolysaccharide detoxification by endotoxin neutralizing protein.
Endotoxin neutralizing protein (ENP), a recombinant form of the anti-lipopolysaccharide factor that was isolated from amebocytes of the American horseshoe crab, Limulus polyphemus, detoxifies lipopolysaccharide (LPS) both in vitro and in vivo. Using the Limulus amebocyte lysate assay, LPS was detoxified by ENP at a 1 to 1 weight ratio (1:1). When isolated rat aortic rings were preincubated for ...
متن کاملHydrophobins—Unique Fungal Proteins
1 Institut National de la Santé et de la Recherche Médicale Unité 872, Paris, France, 2 Université Pierre et Marie Curie – Paris 6, UMR S 872, Centre de Recherche des Cordeliers, Equipe 16-Immunopathology & Therapeutic Immunointervention, Paris, France, 3 Université Paris Descartes, UMR S 872, Paris, France, 4 Institut Pasteur, Unité des Aspergillus, Paris, France, 5 Institut Pasteur, Unité de ...
متن کاملEffect of hyperbaric oxygen and ulinastatin on plasma endotoxin, soluble CD14, endotoxin-neutralizing capacity and cytokines in acute necrotizing pancreatitis.
BACKGROUND We sought to study the effect of a combination therapy comprised of hyperbaric oxygen (HBO) and ulinastatin on the plasma levels of endotoxin, soluble CD14 (sCD14), endotoxin neutralizing capacity (ENC) and cytokines in acute necrotizing pancreatitis (ANP) in rats. METHODS We randomly allocated 90 Sprague-Dawley rats into 6 groups: group 1 (ordinary control), group 2 (sham operatio...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1993
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.4.153